Hybrid Amniotic Membrane Dressing with Green Silver Nanoparticles as Bioengineered Skin for Wounds and Burns
The application of biological wound dressings to heal the skin goes back to centuries to the first written report on the skin xenograft in the 15th century BC as mentioned in the Papyrus of Ebers. Various xenogenic dressings from different animal sources ranging from frogs to porcine skins were in the application. The clinical use of human skin allograft was first described in the manuscript of Branca of Sicily in 1503.
A variety of techniques have been attempted to reduce wound sepsis, and variable results have been reported. Human Amniotic membrane (hAM) is a versatile biological dressing with least ethical/religious problems and elicits neither immunological problems nor allergic responses. hAM has been used with variable success for superficial burns, deep burns, after necrosectomy, on large granulating wound surfaces, on autografts, in donor regions, and after dermabrasion. Though the risk of the transmission of certain viral infections is possible, it can be minimized through proper blood diagnostics and maintenance of aseptic conditions during retrieval of amniotic membrane. Bacterial examinations performed over burn wounds covered with amniotic membrane showed little or no bacterial colonization over open injury.
Hybrid skin grafts derived from electrospun nano fibre have become a new horizon in wound healing. The hybrid electrospun fibres show excellent support for normal human dermal fibroblast (NHDF) cells adhesion and proliferation. Silver nanoparticles act as an antibacterial and also dampen the process of inflammation, thus promoting scarless pro-healing activity.
According to Tian et al. silver nanoparticles can modulate local and systemic inflammatory response following burn injury by cytokine modulation. Moreover, Curcumin is a well-known topical wound healing agent for both regular and diabetic-impaired wounds. Hence we ventured to develop a novel hybrid bandage with the dried amniotic membrane, cord collagen nanofibers and green silver nanoparticles synthesized by curcumin reduction.
Journal of Biotechnology & Biomaterials
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