Compared to western women population, the women folk in India are quite different inbeing more vulnerable to reproductive or gynecologic cancer for the following reasons. Most of the uterine cervical cancer patients in India belong to rural communities. The rural women are unaware of Pap smear test.  Awareness about hormone assay for estrogen and progesterone among the post-menopausal women is totally lacking. These women are also ignorant or careless about self-hygiene of sexual parts or regions. Sexual promiscuity among the male partners being more common the wives of these men are at high risk. For gynecologic cancers, sexually transmitted causative microbes include the syphilitics, spirochete, Trichomonas, vaginalis, Herpes simplex-2, and Human Papilloma virus and HIV etc. The transformation of normal endometrial tissue though promoted by genetic and environmental factors, culturally specific factor and ethnicity also play a causal role. The cancer disease management needs appropriate histopathological cues. The characterization of specific changes could be related to some factors other than specific ethnicity and haplo group origin.