drug administration for brain targeting
Journal of Brain Research, is a peer reviewed, open access journal, This open access journal is published by OMICS International who hosts around 400 open access peer-reviewed journals as well as organizes more than 100 International scientific Conferences. As a Managing Editor it is my great pleasure and honor to welcome you to submit your valuable research work to our Journal.
The acute or chronic drug treatments for different neurodegenerative and psychiatric disorders are challenging from several aspects. The low bioavailability and limited brain exposure of oral drugs, the rapid metabolism, elimination, the unwanted side effects and also the high dose to be added mean both inconvenience for the patients and high costs for the patients, their family and the society. The reason of low brain penetration of the compounds is that they have to overcome the blood-brain barrier which protects the brain against xenobiotics. Intranasal drug administration is one of the promising options to bypass blood-brain barrier, to reduce the systemic adverse effects of the drugs and to lower the doses to be administered. Furthermore, the drugs administered using nasal route have usually higher bioavailability, less side effects and result in higher brain exposure at similar dosage than the oral drugs. In this review the focus is on giving an overview on the anatomical and cellular structure of nasal cavity and absorption surface. It presents some possibilities to enhance the drug penetration through the nasal barrier and summarizes some in vitro, ex vivo and in vivo technologies to test the drug delivery across the nasal epithelium into the brain. Finally, the authors give a critical evaluation of the nasal route of administration showing its main advantages and limitations of this delivery route for CNS drug targeting.
The Journal emphasizes high-level research and education Original research articles, reviews, short communications, and letters to the editors in the fields of Neurosciences are welcome. Every effort is made to have a speedy and critical peer-review process.
Manuscripts can be uploaded at : https://www.scholarscentral.org/submissions/brain-research.html
Journal of Brain Research
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