CD147 Participates in the Function of Angiogenic T Cells in Patients with Rheumatoid Arthritis
CD147 Participates in the Function of Angiogenic T Cells in Patients with Rheumatoid Arthritis
Atherosclerosis: Open Access (Omics Publishing S.L) has announced almost 50 % discount on article processing charge to commemorate its 10th Anniversary.
Atherosclerosis: Open Access is an open access, peer-reviewed journal that focuses and welcomes submissions on all aspects of Coronary Heart disease, Stroke, Peripheral Arterial Disease, Chronic Kidney Disease, arteriosclerosis, Coronary Atherosclerosis, intracranial atherosclerosis etc.
It gives us great pleasure to announce the call for paper on the occasion of 10th Anniversary of the Journal at special and hefty discount of up to 50 % on one-time article processing charge. Prospective academicians and scientists are encouraged to utilize this opportunity to get their articles reviewed, processed and published at relatively faster pace and at lower charges. In addition to this, the authors who publish with us during the year-long celebrations will also be eligible for academic awards recommended by the editorial panel.
The Archive page contains wide variety of articles such as Research / Review / Case reports / short communication / Mini review / Prospective / Letter to Editors Etc. We would like introduce a Research article which has been spread to the widest audience of experts; and thus increased in readership, citations and altimetry score.
Title: “CD147 Participates in the Function of Angiogenic T Cells in Patients with Rheumatoid Arthritis”
Abstract: Rheumatoid arthritis (RA) is a chronic inflammatory and angiogenic disease. This study aims to explore the profiles of circulating angiogenic T cells (Tang cells) and the role of CD147 in Tang cell function in RA. Samples were obtained from RA patients and health controls (HC). Then, Tang cells were quantified by flow cytometry (FCM) in the samples through 87 RA patients and 29 matched HC. Purification of Tang cells was performed by magnetic cell sorting in cell culture conditioned media and the phosphorylation signals were determined by FCM. In addition, cytokine levels were assessed by ELISA test. In RA group, the percentage of circulating Tang cells were intensely increased and positively correlated to endothelial progenitor cells (EPC). Further, the level of Tang cells was closely related to disease activity, autoantibody positivity and pro angiogenic cytokines levels. Meanwhile, the expression of CD147 on Tang cells was increased in RA patients. And CD147 participates in the AKT phosphorylation and VEGF level of the activated Tang cells. It appears that CD147 do play a critical role in regulating VEGF production of Tang cells by affecting AKT signaling, which in turn may serve an essential function in angiogenesis and RA pathogenesis.
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